Health Pro Natural

WEDNESDAY, May 16 (HealthDay News) — A drug approved to treat
advanced prostate cancer appears to help men who have localized high-risk
prostate cancer if given before surgery.

Adding Zytiga (abiraterone) to conventional hormonal treatments
eliminated or nearly eliminated the prostate cancer in one-third of men
with this often-lethal form, according to new research to be presented at
next month’s annual meeting of the American Society of Clinical Oncology
(ASCO) in Chicago.

“This is one of the first — if not the first — study to show that you
can make prostate cancer in the prostate gland itself disappear in a
reproducible number of patients,” ASCO official Dr. Nicholas Vogelzang
said at a Wednesday press conference.

Commenting on the findings, Dr. Jay Brooks, chairman of
hematology/oncology at Ochsner Health System in Baton Rouge, said, “This
is exciting. It’s a novel way to eliminate cancer before surgery.”

However, Brooks, who was not involved in the study, cautioned that the
findings were still preliminary and need further investigation.

Trying to shrink a tumor with chemotherapy and/or radiation before
surgery is standard for other types of cancer, such as breast or colon,
but hasn’t to date shown a benefit in prostate cancer, study author Dr.
Mary-Ellen Taplin, associate professor of medicine at Harvard Medical
School and Dana-Farber Cancer Institute in Boston, explained at the news
conference.

Localized high-risk prostate cancer, which is defined as prostate
cancer in men with a prostate-specific antigen level above 20, high-grade
disease (a Gleason score of 8 or more), and stage T3 disease (indicating
the tumor has spread through the prostate), carries with it a poor
prognosis.

Standard hormonal therapy, which stops the production of male hormones
(androgens), has not been shown to be effective in this type of cancer
when given before surgery. Nor has the surgery, which removes the entire
prostate.

Zytiga blocks production of testosterone, which can promote the growth
of prostate cancer cells, but in a different way than established hormonal
treatments.

This small, phase 2 trial involved 56 men with an average age of 58,
all of whom had had at least three positive biopsies for prostate cancer.

For the first three months, 27 men received the standard hormonal
therapy leuprolide alone, followed by leuprolide plus Zytiga for another
three months.

The remaining 29 men received the two-drug combination for the whole
six months, after which all men in both groups underwent prostate surgery.

One-third of the men who had received leuprolide plus Zytiga for the
entire six months saw complete or nearly complete elimination of their
cancer.

By comparison, only 15 percent of men in the other group experienced
these results, the investigators found.

Those who received the combination for only 12 weeks had much lower
response rates.

The participants also received low doses of the steroid prednisone to
prevent side effects from Zytiga, although side effects overall were
minimal, said Taplin.

It’s not clear at this point why some men responded to the combination
therapy while others did not, and that is an area that needs to be
studied, the researchers said.

“In highly select people who have this aggressive type of prostate
cancer, I think this is an important area to investigate,” Brooks noted.
“We need to figure out which patients would potentially benefit.”

According to study author Taplin, the research received some funding
from
Johnson Johnson, the maker of Zytiga. She said the drug is currently
U.S. Food and Drug Administration-approved for patients with advanced
prostate cancer that does not respond to hormone therapy, and costs about
$5,000 per month.

The data and conclusions of research presented at medical meetings
should be viewed as preliminary until published in a peer-reviewed
journal.

More information

The U.S. National Cancer Institute has more on treatments
for prostate cancer.

Article source: http://news.yahoo.com/advanced-prostate-cancer-drug-may-help-earlier-stage-231827705.html